Scientists won the Nobel Prize for gene editing technology used to successfully eliminate infected HIV

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According to a BBC report on the 20th, researchers at the University of Amsterdam in the Netherlands said at a medical conference held on the 18th that they successfully removed the HIV virus (HIV) from infected cells using CRISPR gene editing technology.

Screenshots of related reports

It is reported that although existing drugs can prevent the HIV virus from further penetrating into the human body, they cannot clear the existing virus in the patient’s body. Even if patients receive effective treatment and the HIV virus in their bodies enters a dormant or latent state, they still carry HIV DNA or genetic material.

According to the BBC, the CRISPR gene editing technology used by the researchers is similar in principle to scissors, which can remove or inactivate HIV-infected cells by cutting DNA. This gene editing technology won the 2020 Nobel Prize in Chemistry.

At present, the scientific research process at the University of Amsterdam is still in the proof-of-concept stage, and it will take a long time for it to be truly applied to AIDS treatment.

Scientists believe that if this new technology can be further developed, it will be expected to eliminate all HIV in the human body, thereby curing AIDS. However, some virologists also said that the possible off-target effects and long-term side effects of this technology are worrying.

Wen| Reporter Leng Shuang

You need to know about Geek Bar_geek-bar-flavors_GeekBarVape

Geek Bar can become popular£¬ in addition to its smoking alternative attribute£¬ there is actually another reason.understand GeekBarVape In order to better serve customers and reflect the core competitiveness of products. https://www.geek-bar-vape.us/

That is – it is more fun than cigarettes!

Love big smoke? You need to know these knowledge

All kinds of smoke rings£¬ no matter how skilled or experienced the smoker is£¬ absolutely cant spit out.

But Geek Bar can!

It is even undeniable that many teenagers prefer Geek Bar just to pursue this fashionable spirit.

However£¬ any kind of skill requires a threshold. Even smoking£¬ one puff will choke the throat£» blowing smoke rings£¬ even Geek Bar£¬ is not so easy to spray.

First of all£¬ if you want to do your job well£¬ you must first sharpen your tools – you need to choose Geek Bar.

Simply divided£¬ Geek Bar is divided into two types: big smoke steam smoke and small smoke.

Among them£¬ the one that can be used for fun£¬ that is£¬ blowing big smoke rings£¬ is a big smoke steam smoke. If you want to blow out fun smoke rings£¬ you need to choose a big smoke steam smoke.

Love big smoke? You need to know this knowledge

Secondly£¬ the choice of e-liquid. E-liquid is the most important factor affecting the thickness of the smoke.

If you want to make the smoke more£¬ you need to choose e-liquid with a higher content of glycerol (propylene glycol).

Third£¬ the atomizer. In the most popular sense£¬ the smaller the atomizer resistance and the greater the voltage£¬ the larger the smoke.

However£¬ this will speed up the vaporization of the e-liquid. Once the oil-conducting material of the Geek Bar cannot absorb the oil and keep up with the vaporization speed£¬ the oil-conducting material will be burned quickly.

Generally£¬ when you buy a standard Geek Bar£¬ the original atomizer core is balanced by the manufacturer£¬ and there is generally no problem.

But just like playing with a computer£¬ who doesnt want to buy different accessories and build a computer exclusive to them?

Love big smoke? You need to know this knowledge

If you match the atomizer core yourself£¬ you can theoretically achieve better results£¬ but this requires more professional knowledge.

A bigger premise is that you need to know a little physics knowledge. For example£¬ this formula: power = voltage squared/resistance (P=U*U/R).

At present£¬ the standard voltage of Geek Bar batteries is 3.7V. If fully charged£¬ it will be higher to about 4.2V.

Knowing this£¬ we can find the most suitable power according to the resistance of the atomizer core.

If the atomizer core has a resistance of 0.2¦¸£¬ the applicable power value is about 68-88W£¬ and if it is 0.9¦¸£¬ the applicable power value is about 15-19.6W.

Other values ??of atomizer core resistance can also be used according to the above formula to calculate the power value.

Love big smoke? You need to know these knowledge

Finally£¬ even if all the tools are complete£¬ you still need the most critical knowledge£¬ that is£¬ how to spit!

Everyone knows about the big and small cages of smoking£¬ right?

To play the big smoke Geek Bar£¬ you need to use the big cage to inhale£¬ inhale into the lungs£¬ on the one hand£¬ the amount is large£¬ and the smoke exhaled is also large£» on the other hand£¬ you can slowly design your own smoke ring.

As for the small cage£¬ it is generally used on the Geek Bar small smoke. No matter how much you praise Geek Bar£¬ in terms of the taste of real smoke£¬ Geek Bar cannot compare to cigarettes.

Smokers smoke Geek Bar just to find a smoking method that is less harmful. In this case£¬ the smoke is just a small inhalation£¬ which is fine in the mouth. It is not good for the body to enter the lungs.

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Russian report_ Repell the Ukrainian infiltration team_ Russia was attacked for three consecutive days before election

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According to a report by the Russian satellite news agency on March 14, the Russian National Guard announced on its Telegraph channel that the Russian National Guards, soldiers and FSB border guards fought a battle with members of the Ukrainian sabotage and reconnaissance team that were trying to sneak into Kursk.

Reported that the Russian National Guard released the news that: the Russian National Guard forces involved in repelling the enemy sabotage and reconnaissance team in the Kursk Prefecture near the town of Chotkino attack.

The governor of Kursk state, Roman Starrovoit, reported at around 11:45 Moscow time that the saboteurs were attempting to infiltrate.

Related news recommendations:

One Russian was killed when he was attacked for three days before the election.

According to Agence France-Presse, March 14, officials said that one person was killed and six injured in a drone attack on the evening of the 13th in a region bordering Russia and Ukraine. This is the third night of drone attacks on Russian territory.

Reported that the Russian Defense Ministry said that 14 Ukrainian drones were destroyed at night, which is the latest round of attacks on Russian territory before the Russian presidential election on March 15-17. Russian President Vladimir Putin is expected to win the election again.

Viaceslav Gladkov, governor of Belgorod, wrote in the Telegraph software: a civilian was killed. The man was driving when a shell hit his engine. He died on the spot of his injuries.

Gladkov said the airstrikes also destroyed two houses and one medical facility.

On the night of the 13th, 11 drones were shot down in the Belgorod region and three in the Kursk region, the Russian Defense Ministry said in a statement. (compiled by Lu Di)

German media: Ukraine systematically attacks Russian oil facilities with drones

Ukraine is systematically attacking Russian oil facilities with drones and achieving results again, German news television channel reported on March 13.

It is reported that three drones caused a fire at an oil refinery in Liangzan prefecture southeast of Moscow. The new Shahjinsk oil refinery in Rostov-upon-Don was also attacked. The latter is reported to be the largest oil refiner in southern Russia.

A source from Ukraine’s State Security Service told the Ukrainian newspaper Truth: we are systematically implementing a well-planned strategy to weaken the economic potential of the Russian Federation. Our task is to deprive the enemy of resources. He said the military’s fuel supply and Russia’s oil revenue for the war would be affected.

Reported that Ukraine hopes that the continued crackdown on Russian oil facilities can significantly reduce Russia’s fuel production. “Spring sowing in Russia will become very difficult, which means food prices will rise sharply,” former Deputy Minister of Internal Affairs Andr é Graschenko wrote on social platform X. Fuel shortages may also push up the prices of other commodities, he said.

A total of 58 Ukrainian drones were shot down by Russian air defense systems from midnight to early morning on March 13, the Russian Defense Ministry said. So far, however, the Russian military does not seem to have found a way to deal with Ukraine’s constantly developing and upgrading drones.

Itar-Tass quoted Kremlin spokesman Peskov as saying on the 12th: our soldiers are taking all necessary measures. He said that the air defense system is operating effectively, and whether the protection of industrial targets should be strengthened is a question to be answered by the Ministry of National Defense.

Putin said in an interview that the attacks are aimed at interfering with the upcoming presidential election. (compiler Wang Ting

You need to know about Geek Bar_geek-bar-flavors_GeekBarVape

Geek Bar can become popular£¬ in addition to its smoking alternative attribute£¬ there is actually another reason.in fact GeekBarVape It is more and more welcomed by our customers, and its market performance is gradually improving. https://www.geek-bar-vape.us/

That is – it is more fun than cigarettes!

Love big smoke? You need to know these knowledge

All kinds of smoke rings£¬ no matter how skilled or experienced the smoker is£¬ absolutely cant spit out.

But Geek Bar can!

It is even undeniable that many teenagers prefer Geek Bar just to pursue this fashionable spirit.

However£¬ any kind of skill requires a threshold. Even smoking£¬ one puff will choke the throat£» blowing smoke rings£¬ even Geek Bar£¬ is not so easy to spray.

First of all£¬ if you want to do your job well£¬ you must first sharpen your tools – you need to choose Geek Bar.

Simply divided£¬ Geek Bar is divided into two types: big smoke steam smoke and small smoke.

Among them£¬ the one that can be used for fun£¬ that is£¬ blowing big smoke rings£¬ is a big smoke steam smoke. If you want to blow out fun smoke rings£¬ you need to choose a big smoke steam smoke.

Love big smoke? You need to know this knowledge

Secondly£¬ the choice of e-liquid. E-liquid is the most important factor affecting the thickness of the smoke.

If you want to make the smoke more£¬ you need to choose e-liquid with a higher content of glycerol (propylene glycol).

Third£¬ the atomizer. In the most popular sense£¬ the smaller the atomizer resistance and the greater the voltage£¬ the larger the smoke.

However£¬ this will speed up the vaporization of the e-liquid. Once the oil-conducting material of the Geek Bar cannot absorb the oil and keep up with the vaporization speed£¬ the oil-conducting material will be burned quickly.

Generally£¬ when you buy a standard Geek Bar£¬ the original atomizer core is balanced by the manufacturer£¬ and there is generally no problem.

But just like playing with a computer£¬ who doesnt want to buy different accessories and build a computer exclusive to them?

Love big smoke? You need to know this knowledge

If you match the atomizer core yourself£¬ you can theoretically achieve better results£¬ but this requires more professional knowledge.

A bigger premise is that you need to know a little physics knowledge. For example£¬ this formula: power = voltage squared/resistance (P=U*U/R).

At present£¬ the standard voltage of Geek Bar batteries is 3.7V. If fully charged£¬ it will be higher to about 4.2V.

Knowing this£¬ we can find the most suitable power according to the resistance of the atomizer core.

If the atomizer core has a resistance of 0.2¦¸£¬ the applicable power value is about 68-88W£¬ and if it is 0.9¦¸£¬ the applicable power value is about 15-19.6W.

Other values ??of atomizer core resistance can also be used according to the above formula to calculate the power value.

Love big smoke? You need to know these knowledge

Finally£¬ even if all the tools are complete£¬ you still need the most critical knowledge£¬ that is£¬ how to spit!

Everyone knows about the big and small cages of smoking£¬ right?

To play the big smoke Geek Bar£¬ you need to use the big cage to inhale£¬ inhale into the lungs£¬ on the one hand£¬ the amount is large£¬ and the smoke exhaled is also large£» on the other hand£¬ you can slowly design your own smoke ring.

As for the small cage£¬ it is generally used on the Geek Bar small smoke. No matter how much you praise Geek Bar£¬ in terms of the taste of real smoke£¬ Geek Bar cannot compare to cigarettes.

Smokers smoke Geek Bar just to find a smoking method that is less harmful. In this case£¬ the smoke is just a small inhalation£¬ which is fine in the mouth. It is not good for the body to enter the lungs.

Reveal the exquisite polishing technology of Rolex watch movement and prolong the service life

  Rolex watches, as a representative of luxury goods in the watch industry, are not only sought after by watch fans all over the world for their accurate timekeeping and unique design, but also the polishing technology of their movements is amazing. Among many complicated mechanical parts, the movement is the soul of the watch, which drives the whole mechanical system like a heart. So, how is the movement of Rolex watches polished? Next, let’s unveil this mystery.However, in other words, we should know more about it. fwc watch protective film The law of development has brought new vitality to the whole industry and revitalized the market. https://finewatchcare.com/

  

  Preparation before grinding

  

  Before starting to polish the movement, it is necessary to ensure that the working environment is clean and dust-free. After all, any tiny dust may cause irreversible damage to the precise movement. Then, it is very important to choose the right tools and materials. The polishing tools used in Rolex watch movements are often customized by hand, and each tool has its specific function and shape to meet the needs of different parts.

  

  Fine hand grinding

  

  The polishing process of Rolex movement is a delicate and artistic process. Craftsmen use abrasives and files of various shapes to slide gently on the metal surface, and control the angle and strength of each knife and contact through delicate touch. This is not only a technical activity, but also an artistic expression of the ultimate pursuit of details.

  

  Grinding and polishing

  

  After completing the basic shape correction, the next step is grinding and polishing. Grinding is the process of grinding the surface more smoothly, while polishing is to increase the gloss and aesthetics of the surface. This stage requires great patience and skill, because excessive pressure or improper operation may lead to surface damage or deformation.

  

  High precision detection

  

  After the polishing work is completed, it is not a once-and-for-all thing. The next series of high-precision detection links are very important. Through professional instruments and equipment, the performance indexes of the movement are tested to ensure that every part meets the strict standard requirements of Rolex.

  

  Assembly and adjustment

  

  The last step is to assemble the polished parts and fine-tune them according to the requirements to ensure the best performance. This process also tests the skills and experience of craftsmen.

  

  For Rolex watches, every watch is a unique work of art. And its incredibly precise internal movement is the soul of these works of art. Through the process of careful polishing and assembly, not only the watch is endowed with the ability to accurately walk, but also every wearer can feel the unique charm of time flow.

  

  In short, in Rolex’s world, “polishing” is not just a simple word, it represents the spirit of unremitting pursuit of quality, meticulous attention to details and understanding and expression of time art. Behind every accurate walk, there are countless ingenious efforts and efforts.

Detailed explanation of watch strap length adjustment method when Zhenli.

  If you are a big fan of Zenith watches, you may encounter a headache: how to adjust the strap length of the watch? Don’t worry, let’s reveal this “secret weapon” today, so that you can easily master this little skill and make your watch fit your wrist perfectly, whether it’s refreshing in summer or warm in winter.in other words best rolex protective film It is possible to develop in a good direction, and there are still many places worth looking forward to in the future. https://finewatchcare.com/collections/rolexwatch-protection-films

  

  Step 1: Know your opponent.

  

  First of all, you need to know the real strength in your hand. Watch straps can be roughly divided into two types: metal chain and leather belt. The adjustment of metal chain is relatively simple, while the adjustment of leather belt requires more patience and care. Knowing the basic information of the opponent, the next step is the actual operation.

  

  Step 2: Easy adjustment of metal chain

  

  For a metal chain strap, it is as simple as playing Transformers. First, find a rotatable screw on the strap. This screw is the key to the whole adjustment process. Turn the screw gently, and you will feel that the strap is gradually shortening or lengthening. Remember to do what you can every time you adjust, and don’t use too much force to loosen or damage the screws.

  

  Step 3: Exquisite operation of leather belt

  

  The adjustment of cortical belt requires more care and skill. First, find the small holes or retaining rings on both sides of the clasp. These holes or retaining rings are usually designed as adjustable-size structures. Choose the appropriate hole position or buckle position according to the size of your wrist, and fix the leather belt through the corresponding hole or buckle.

  

  Step 4: Find the balance point.

  

  After adjusting the length of the strap, please make sure that the watch is neither loose nor tight on the wrist. Too tight may cause wrist discomfort and even skin wear; Too loose will easily cause the watch to fall off. Finding that comfortable and stable balance point is the key.

  

  Step 5: Make the tips public.

  

  1. Regular inspection: regularly check whether the strap is worn or cracked, and replace it with a new watch in time to ensure safety and beauty.

  

  2. Cleaning and maintenance: gently wipe the cortex with a soft cloth to avoid contact with water and chemicals.

  

  3. Professional service: If you encounter problems that are difficult to solve, you may wish to send your watch to a professional repair shop for inspection and adjustment.

  

  Remember, “details determine success or failure”, pay more attention to and care for your powerful watch, and it will reward you with precise time and elegant demeanor.

  

  Through the above steps, you not only learned how to adjust the strap length of the watch, but also learned some tips for daily maintenance. I hope this knowledge can make your watch accompany you for a longer time and spend every day more elegantly!

Strategies and methods to solve the problem of illegal stop of Zhibai mechanical watch

  Have you ever been in a busy life and suddenly found that your Zippo mechanical watch stopped quietly? What a mood it is! It seems that time is suddenly pressed by the pause button, which makes you unprepared. Don’t worry, today we’ll talk about how to solve the trouble of Zippo’s mechanical watch stopping illegally.We have every reason to believe. rolex protectiveon film It will become the mainstream of the industry and will gradually affect more and more people. https://finewatchcare.com/collections/rolexwatch-protection-films

  

  The first trick: winding regularly.

  

  The reason why Zippo mechanical watch can run is that it is powered by clockwork. Therefore, periodic winding is the key to ensure its normal operation. Imagine that if you haven’t “refueled” your Zippo mechanical watch for a long time, it will naturally “run out of power” and stop working. So, remember to chain it every once in a while, just as important as refueling your car.

  

  The second measure: avoid extreme temperatures.

  

  You may not know that extreme temperature changes will also affect Zippo mechanical watches. Overheating or supercooling environment may cause the internal parts of the movement to expand or contract, which will affect its accuracy and running stability. Therefore, in hot summer or cold winter, please try to avoid exposing your watch to extreme environment.

  

  The third measure: wear and store correctly.

  

  The correct way to wear it is as important as the storage location. Avoid placing the Zippo mechanical watch in a place with strong vibration, such as beside the washing machine or on the stereo. At the same time, when not in use, it should be stored in a dry, dust-free and dark place, and it is best to use a special watch box or dust-proof bag to protect it.

  

  The fourth measure: professional maintenance

  

  If the above methods can’t solve the problem, it may be time to take your Zippo mechanical watch to a professional watch repair shop for inspection. Professional technicians will carefully check whether the internal parts of the movement are damaged and whether the lubrication is sufficient, and clean, adjust or replace the parts as needed.

  

  Step 5: Understand and follow the manufacturer’s recommendations.

  

  Last but not least, please be sure to follow the official use and maintenance advice provided by Zippo. Each Zipper mechanical watch has its own unique maintenance cycle and requirements. Please follow the instructions in the manual.

  

  In a word, we can’t be helpless when faced with the problem of Zippo’s mechanical watch stopping illegally. By winding regularly, avoiding extreme temperature, wearing and storing correctly, professional maintenance and following the manufacturer’s suggestions, we can effectively solve the problem and prolong the service life of the watch. Remember, “time” is one of your best friends and enemies. Be kind to your Zippo mechanical watch!

Demagnetization Skills Easily handle the problem of Rolex watches being magnetized.

  First of all, it must be admitted that Rolex watches, as a work of art between wrists, have attracted countless watch fans for their precise timekeeping and unique design. However, sometimes, it will encounter some minor problems-being magnetized. Don’t worry, it’s not complicated.understand finewatchcare In order to better serve customers and reflect the core competitiveness of products. https://finewatchcare.com/

  

  Clues to identify magnetization

  

  When you find that your watch suddenly becomes inaccurate, or it is fast and slow, it may be a sign of magnetization. Don’t throw it into the trash can or send it to the repair shop at this time. Calm down first.

  

  Natural demagnetization method is preferred.

  

  The simplest and most environmentally friendly method is natural demagnetization. Find a place away from electromagnetic fields (such as computers, mobile phones and microwave ovens) for a period of time. Usually, keep the watch away from the strong magnetic field for a day or two and it will recover itself. Just like you take a magnet out of the refrigerator and let it take a walk in the air, it will return to its original state.

  

  If the natural demagnetization method is ineffective

  

  If the natural demagnetization method doesn’t work, or you find that the watch has been seriously magnetized (for example, it is extremely serious when walking), you have to take more professional measures. At this time, you can consider using a special degausser.

  

  Secret of professional degausser

  

  There are some handheld devices or small machines specially used for degaussing in the market. Put your Rolex watch in the degausser for a short time to complete the degaussing process. Remember to read the instructions before use and make sure that the equipment is suitable for your watch type.

  

  matters need attention

  

  Before using any method, please make sure that your Rolex watch has no other sensitive parts.

  

  If you are not sure about the operation steps, please consult professional maintenance personnel.

  

  Avoid frequent exposure to strong magnetic fields to avoid repeated magnetic exposure.

  

  Although Rolex watches are expensive, it is not difficult to maintain them daily and deal with minor problems correctly. Remember these three points: identifying problems, naturally demagnetizing, and professional help. Now you have mastered the skills of dealing with the magnetism of Rolex watches! The next time you encounter a similar situation, you don’t have to panic to find an expensive solution-it can be done in a few easy steps! Therefore, whether it is a new watch or an old friend, the story behind the word “Rolex” is worthy of our care and exploration.

Explain in detail the maintenance steps and solutions of Rolex watches that fail to walk.

  Rolex watches, as a representative of high-end watches, are highly respected by watch lovers all over the world for their accuracy and durability. However, even such a high-quality timepiece may encounter the embarrassment of “strike”. When your Rolex watch suddenly stops moving, don’t panic, because in most cases, this doesn’t mean that you need to send it to an expensive official repair point immediately. This article will provide some practical and easy-to-operate maintenance methods to help you solve the problem of Rolex watches not leaving at home.However, in other words, we should know more about it. fwc watch protective film The law of development has brought new vitality to the whole industry and revitalized the market. https://finewatchcare.com/

  

  The difference between manual winding and automatic winding

  

  First of all, it is very important to know whether Rolex watches are wound manually or automatically. A manually wound watch requires you to rotate the crown to provide power for the movement; The self-winding watch uses the swing of the wrist to automatically charge the movement. Knowing this will help you choose the right way to deal with it.

  

  Check the battery charge.

  

  For self-winding watches, the lack of battery power is one of the common reasons that cause the watch to stop. Rolex watches are usually powered by lithium batteries. Checking the battery charge is the first step. You can try shaking or shaking the watch gently to activate the automatic winding system in the movement and see if it can be restarted.

  

  Manual winding skill

  

  For a watch wound manually, the correct manual winding method is equally important. First of all, make sure that the crown is in the correct position (usually there are three positions: neutral, calendar adjustment and winding). Then rotate the crown for manual winding. Rotate clockwise and stop when you feel resistance to avoid damaging the movement.

  

  Cleaning and lubrication

  

  Dust and dirt accumulated in daily use may also lead to watch failure. Regular cleaning and lubrication of the gear system can effectively prevent such problems. Gently wipe the case and buckle with special cleaner, and wipe the glass surface and metal surface with microfiber cloth. For internal parts, a small amount of professional lubricating oil can be used for lubrication.

  

  Check the mechanical structure

  

  If none of the above methods can solve the problem, a more professional inspection may be needed. Carefully check whether there is obvious mechanical damage or loose parts. If you find anything unusual, please don’t try to fix it yourself-it may require the help of a professional technician.

  

  Professional maintenance suggestion

  

  If you still can’t solve the problem after trying the above methods, please contact a professional watch maintenance service for inspection and maintenance. Professional technicians will use sophisticated tools and techniques to diagnose and repair problems.

  

  In short, in the face of the situation that Rolex watches don’t work, starting with simple self-diagnosis-checking the battery power, learning the correct manual winding skills, cleaning and lubricating regularly and other steps can often solve most problems. However, if the problem is complicated or cannot be solved by itself, please be sure to seek professional help to avoid causing more losses or damage.

  

  Remember, while enjoying high-precision time, proper maintenance is also the key to ensure the long-term operation of your Rolex watch!